1. "Talking to Machines" This hour of Radiolab, Jad and Robert meet humans and robots who are trying to connect, and blur the line. We begin with a love story--from a man who unwittingly fell in love with a chatbot on an online dating site. Then, we encounter a robot therapist whose inventor became so unnerved by its success that he pulled the plug. And we talk to the man who coded Cleverbot, a software program that learns from every new line of conversation it receives...and that's chatting with more than 3 million humans each month. Then, five intrepid kids help us test a hypothesis about a toy designed to push our buttons, and play on our human empathy. And we meet a robot built to be so sentient that its creators hope it will one day have a consciousness, and a life, all its own. 2. "Games" A good game--whether it's a pro football playoff, or a family showdown on the kitchen table--can make you feel, at least for a little while, like your whole life hangs in the balance. This hour of Radiolab, Jad and Robert wonder why we get so invested in something so trivial. What is it about games that make them feel so pivotal? We hear how a recurring dream about football turned into a real-life lesson for Stephen Dubner, we watch a chessboard turn into a playground where by-the-book moves give way to totally unpredictable possibilities, and we relive a moment where rooting for the underdog makes us rethink what a truly happy ending is. 3. "Loops" Our lives are filled with loops that hurt us, heal us, make us laugh, and, sometimes, leave us wanting more. This hour, Radiolab investigates the strange things that emerge when something happens, then happens again, and again, and again, and again, and again, and … well, again. In this episode of Radiolab, Jad and Robert try to explain an inexplicable comedy act, listen to a loop that literally dies in your ear, and they learn about a loop that sent a shudder up the collective spine of mathematicians everywhere. Finally, they talk to a woman who got to watch herself think the thought that she was watching herself think the thought that she was watching herself think the thought that ... you get the point. All that plus mind-bending musical accompaniment from Laguardia Arts High School singers Nathaniel Sabat, Julian Soto, Eli Greenhoe, Kelly Efthimiu, Julia Egan, and Ruby Froom. 4. "Patient Zero" The greatest mysteries have a shadowy figure at the center—someone who sets things in motion and holds the key to how the story unfolds. In epidemiology, this central character is known as Patient Zero—the case at the heart of an outbreak. This hour, Radiolab hunts for Patient Zeroes from all over the map. We start with the story of perhaps the most iconic Patient Zero of all time: Typhoid Mary. Then, we dive into a molecular detective story to pinpoint the beginning of the AIDS, and we re-imagine the moment the virus that caused the global pandemic sprang to life. After that, we're left wondering if you can trace the spread of an idea the way you can trace the spread of a disease. In the end, we find ourselves faced with a choice between competing claims about the origin of the high five. And we come to a perfectly sensible, thoroughly disturbing conclusion about the nature of the universe ... all by way of the cowboy hat. 5. "The Bad Show" Cruelty, violence, badness... This episode of Radiolab, we wrestle with the dark side of human nature, and ask whether it's something we can ever really understand, or fully escape. We begin with a chilling statistic: 91% of men, and 84% of women, have fantasized about killing someone. We take a look at one particular fantasy lurking behind these numbers, and wonder what this shadow world might tell us about ourselves and our neighbors. Then, we reconsider what Stanley Milgrim's famous experiment really revealed about human nature (it's both better and worse than we thought). Next, we meet a man who scrambles our notions of good and evil: chemist Fritz Haber, who won a Nobel Prize in 1918...around the same time officials in the US were calling him a war criminal. And we end with the story of a man who chased one of the most prolific serial killers in US history, then got a chance to ask him the question that had haunted him for years: why? 6. "Escape!" The walls are closing in, you've got no way out... and then, suddenly, you escape! This hour, stories about traps, getaways, perpetual cycles, and staggering breakthroughs. We kick things off with a true escape artist--a man who’s broken out of jail more times than anyone alive. We try to figure out why he keeps running... and whether he will ever stop. Then, the ingeniously simple question that led Isaac Newton to an enormous intellectual breakthrough: why doesn’t the moon fall out of the sky? In the wake of Newton's new idea, we find ourselves in a strange space at the edge of the solar system, about to cross a boundary beyond which we know nothing. Finally, we hear the story of a blind kid who freed himself from an unhappy childhood by climbing into the telephone system, and bending it to his will. 7. "Guts" This hour, we dive into the messy mystery in the middle of us. What's going on down there? And what can the rumblings deep in our bellies tell us about ourselves? We stick our hand in a cow stomach, get a window into our core (thanks to a hunter who became a walking science experiment in the 1800s), and listen in on the surprising back-and-forth between our gut and our brain. And we talk to a man who kind of went out of his mind when a medical procedure left him (for a little while) gutless. 8. "Colors" Our world is saturated in color, from soft hues to violent stains. How does something so intangible pack such a visceral punch? This hour, in the name of science and poetry, Jad and Robert tear the rainbow to pieces. To what extent is color a physical thing in the physical world, and to what extent is it created in our minds? We start with Sir Isaac Newton, who was so eager to solve this very mystery, he stuck a knife in his eye to pinpoint the answer. Then, we meet a sea creature that sees a rainbow way beyond anything humans can experience, and we track down a woman who we're pretty sure can see thousands (maybe even millions) more colors than the rest of us. And we end with an age-old question, that, it turns out, never even occurred to most humans until very recently: why is the sky blue? 9. "When Brains Attack" In this episode, strange stories of brains that lead their owners astray, knock them off balance, and, sometimes, propel them to do amazing things. We hear from a kid whose voice was disguised from himself, relive a surreal day in the life of a young researcher hijacked by her own brain, and try to keep up with an ultra-athlete who, after suffering terrible seizures, gained extraordinary abilities by removing a chunk of her brain. 10. "Ghost Stories" Ghosts, ghouls, shades from the past ... in this episode of Radiolab, real-life people try to pin down, and make peace with, mysterious figures that haunt them, prod them, and fade out of existence. One man finds a way to put the beatdown on his personal bogey man, a dead monk spurs a king to build a perfect prayer machine, an unknown face launches a thousand dummies (actually, a whole lot more than that), and a skeptic goes on a one-way to journey to find out whether spirits exist.